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The Syndromic Surveillance for Epidemiological Investigation - Response Protocols for Disease Detection guides the target audience of both public heath and hospital workers in the understanding and development of response protocols to surveillance alerts. Content is a web-based course that introduces the concept of response protocols and guides users on developing and using response protocols through a series of modules. A learning self-assessment is provided in the form of interactive scenarios prompting response to questions and providing answers with explanation. The product's content was tested at the 2009 Public Health Preparedness Summit through classroom didactic and evaluation forms. The requirements were vetted through CDC BioSense and local health department epidemiology reviews.